Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion inadult rats

Background and Objective: The aim was to investigate the protective Effect Fumaria parviflora extract on sperm parameters, tissue damage and oxidative stress induced by testicular torsion Materials and Methods: Animals were randomly divided into a sham group and three exprimental groups. The first group: testicular torsion fallowing by detorsion (TD), the second group: testicular torsion detorsion Fallowed by receiving the extract of Fumaria parviflora (FP) (TDFP) and third group: receiving the extract of FP without TD (FP) .Testicular torsion was induced by 720-degree counterclockwise rotation of the left testis for the 4 h. after duration of torsion, detorsion was doing. Animals were given by daily oral administrations FP (250 mg/kg) for 14 days. Measurement of the oxidative stress, sperm parameters, testosterone levels and assessments of Histo morphometry 14 days after detorsion was conducted. Findings: The Johnsen’s score, diameter of the seminiferous tubules and thickness of seminiferous tubule epithelium significantly increased and decreased the index of apoptosis in TDFP group when compared with the TD group. Also treatment with FP extract was improved the sperm parameters in TDFP and FP groups as compared with TD group. The level of testosterone and GPX increased significantly in testicular torsion group that treatment with FP extract (TDFP) compared with TD group. The MDA level also decreased in the testicular torsion group receiving the extract of FP (TDFP) compared with the TD group. Conclusions: The findings of the current study suggested that Fumaria parviflora might have provided a protective effect against TD induce oxidative stress injury.

کلیدواژه ها:

apoptosis ، Fumaria parviflora ، oxidative stress markers ، testicular torsion–detorsion