Study of prevalence (HLA-A*3101 ) polymorphism association with Carbamazepine medicine prescription in different Iranian ethnicity

Pharmacogenetics is the study of medicines and their interactions as well as individuals’ genotype. Single medicines have different impacts on different people. Some people need greater or lesser doses of medicines in order to achieve a therapeutic effect similar to the ones obtained in others.Human leukocyte antigen (HLA) is the most polymorphic genetic system in human beings and is also known as major histocompatibility complex (MHC). Modulation of the immune response is the key role of HLA molecule. Human MHC has been mapped on the short arm of chromosome 6 (6p21). Human HLA has a total of 120 loci and 554 allele and covers about 1/3000 of the entire human genome.HLA is a unique tool to study the genetic relationships between different populations. A strong signal in the MHC region is identified using a few SNPs (Single nucleotide polymorphism) around the HLA-A area.HLA-A * 31: 01 is common allele on the HLA genes this is known as the most common genetic markers for prediction of hypersensitivity to carbamazepine. This medicine is used to treat epilepsy and bipolar disorders and leads to mild to severe allergies, as well as death in some cases.It is proved that the HLA-A * 31: 01 allele causes hypersensitivity to carbamazepine and is also used to predict the occurrence of hypersensitivity to carbamazepine. A Significant correlation has been observed between the HLA-A * 31: 01 allele and carbamazepine hypersensitivity syndrome (HSS) and maculopapular Eczema (MPE).A Definite Background on the relationship between rs1061205 and HLA-A * 3101 allele has already been observed. The present study is an attempt to investigate the presence or absence of HLA-A * 31: 01 allele among all the Iranian 10 ethnic groups(300 person), as a response with high resolution.

کلیدواژه ها:

pharmacognetic ، hla ، carbamazepin ، polymorphism