Naringenin impacts on SkBr3 and BT-474 human breast cancer cells: A systematic review

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 315

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شناسه ملی سند علمی:

IPMCMED01_151

تاریخ نمایه سازی: 23 آذر 1397

چکیده مقاله:

Background: Top cancer in woman throughout worldwide is breast cancer. Recently, natural remedies such as Naringenin (Nar) - a kind of flavonoids which it can be found in oranges grapefruits and tomatoes- seem to be interesting that might play a useful role in chemoprevention because of possesses pleiotropic molecular mechanisms of action on breast cancer cells.Objective: We performed a PRISMA-directed systematic review to investigate the effects of Naringenin on some human breast cancer cells (SkBr3 and BT-474). Cytotoxicity, tumor size, apoptosis and estrogenic properties were assessed as primary outcomes.Methods: The systematic search without restriction was conducted in the electronic databases including PubMed, Scopus, Google scholar, Cochrane Library before Dec 2016. Results: Initially, 6137 articles were identified. After screening title and abstract, 21studies were selected for text appraisal. Finally, 4 articles which met the inclusion criteria were evaluated. Based on the evaluation, Nar at different concentration can inhibit both cell proliferation and tumor growth. Also it can induce apoptosis.Conclusion: Due to anticancer properties of Nar, some probably mechanisms that provide these effects are inducing alteration in, caspase and aromatase enzymes, and suppression of oestrogen signal transduction pathways. However, more investigations will be necessary in future to decide whether Nar consumption is recommendable as a part of breast cancer control. Also designing some clinical trials are needed to determine the optimal dose for therapeutic use.

نویسندگان

Farnaz Parvaresh

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Zahra Akbarzade

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran