The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population

Cytochrome P450 1A2 (CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene, CYP1A2, a hepatic enzyme inducible by smoking, metabolizes various chemical procarcinogens, such as food-derived heterocyclic and aromatic mutagens, N-heterocyclics found in tobacco smoke, and difuranocoumarins, to reactive carcinogens.there are many epidemiological reports examining the role of variant CYP1A2, metabolism of procarcinogens and cancer risk. The enzyme has a significant role in chemical carcinogenesis and is induced by its substrates. CYP1A2*1K, rs762551:C > A plus rs2069526:T > G, and rs12720461:C > T showed decreased metabolism Subjects with CYP1A2*1K hadsignificantly decreased CYP1A2 activity in vivo, and reporter constructs with this haplotype had significantly less inducibility with 2,3,7,8-tetrachlorodibenzo-p-dioxin. CYP1A2*1K polymorphism is decreased the effect of drugs in human ovarian carcinoma cell.

کلیدواژه ها:

Gastric cancer ، Bioinformatics ، miRNA ، Metastasis ، Stemness ، Drug Resistance