Hamidreza Agha Heydarali Naghash - Karaj Branch, Islamic Azad University,Karaj,Iran
Ali Salehzadeh - Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran
Ashkan Alborzi - Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
Shima Forouzan - Islamshahr Branch, Islamic Azad University, Islamshahr, Iran

Several epidemiological studies have evaluated the association between TNRC9 (also known as TOX3) polymorphisms and breast cancer risk, but the results remain inconclusive according to different ethnic groups (Zheng et al., 2009; Li et al., 2009; Ruiz-Narváez et al., 2010).TOX3 the locus on 16q includes a gene TNRC9 and a hypothetical gene LOC643714. TOX3 is a gene of uncertain function containing a trinucleotide repeat motif and encoding a member of the high-mobility group family of non-histone chromatin proteins. The presence of a putative high-mobility group box motif suggests that it might function as a transcription factor (Easton et al., 2007). Several studies have shown that susceptibility loci at TOX3 predispose to sporadic breast cancer.The TOX3/LOC643714 locus on chromosome 16q12.1 was one of the first breast cancer regions identified through genome-wide association study (GWAS) in populations of European and East Asian Origin.5 SNPs including rs3803662, rs12443621, rs8051542, rs3104746 and rs4784227 inTOX3 and the hypothetical gene LOC643714 identified novel risk loci for breast cancer in populations of European and East Asian origin.In this study, we will evaluate the association between TOX3 polymorphisms ( rs3803662 , rs12443621, rs8051542, rs3104746 and rs4784227 ) and breast cancer risk in Persian women.

TOX3,breast cancer , SNP,association, polymorphism