Role of Entegrins in Wound Repair and its Periodontal Emplications
- سال انتشار: 1397
- محل انتشار: سومین کنگره بین المللی و پنجمین کنگره ملی زخم و ترمیم بافت
- کد COI اختصاصی: WTRMED05_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 498
نویسندگان
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
چکیده
Wound healing in human periodontium is a complex process which involves both cell-cell and cell-matrix interactions. Entegrins play a major role in regulation of these cell-cell, cell-matrix interaction. Wound healing involves two major events i.e. re-epithelialization and connective tissue repair. In this concise review, we will discuss the role of integrins in these major events as well as their impIications in periodontal wound repair. Entegrins are differentially expressed in both of these major events. In re-epithelialization, keratinocytes express novel integrins receptors alphavB1, alpha5B1and alphavB6 which are not expressed in normal healthy epithelium. Re-epithelialization also involves interaction of integrins with TGF-B and fibronectin. Similarly, in connective tissue repair, the activation of fibroblast as well as the expression of integrins alpha5B1 and alpha3B1 is upregulated. In healthy periodontium, integrin alphavB6 is normally expressed in junctional epithelium which is generally expressed only at wound sites in other parts of the body. The epithelialization at implant surface has not been yet fully explored with respect to interactions among integrins and other extra-cellular matrix molecules.کلیدواژه ها
Fibroblasts, Entegrins, Keratinocytes, Periodontium, Wound Repairمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.