Curcumin to Abrogate Structural Changes in the Locus Coeruleus Following Chronic Sleep Restriction in Rats
- سال انتشار: 1397
- محل انتشار: اولین کنگره بین المللی علوم اعصاب (نوروتکنولوژی و نقشه برداری مغزی)
- کد COI اختصاصی: NSMED01_031
- زبان مقاله: انگلیسی
- تعداد مشاهده: 542
نویسندگان
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
This study examined the consequences of chronic sleep restriction (CSR) with or without curcumin treatment on quantitative histomorphological correlates of the locus coeruleus (LC) nucleus using stereological techniques. Male rats were assigned to four groups including: 1-control (C), 2- grid floor (GF), 3- CSR and 4- CSR+ curcumin (CUR) (100 mg/kg/day). Animals in the GF group were placed on wire-mesh grids while in the CSR box (modified multiple platform paradigm). After a period of 21 days, rats were sacrificed with their brains excised and assessed using stereological procedures. Our findings revealed a 22%, 45% and 47% reduction in the total volume, the total number of neurons and glial cells of LC in CSR group as compared to the control groups, respectively (p < 0.01). Such structural changes were abrogated in the CSR+CUR compared to the CSR group. The study outcome proposed potential neuroprotective effects of CUR in our sleep-restricted rat model.کلیدواژه ها
Curcumin, Locus Coeruleus, Chronic Sleep Restrictionاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.