Precancerous Cutaneous Lesions

Precancerous cutaneous lesions are potentially in situ carcinomas that may change to true carcinomas. So early diagnosis and treatments are very important. There are many risk factors for developing precancerous lesions (or cancers) including UV radiation, human papillomaviruses, genetic factors, … .Examples of common precancerous cutaneous lesions are actinic keratosis, keratoacanthoma, cutaneous horn, Bowen’s disease and verrucous carcinoma.Actinic keratoses (AKs) present on sun-damaged skin of the head, neck, upper trunk, and extremities. The primary lesion is a rough erythematous papule with white to yellow scale. Patients may report tenderness. AKs can range in size from a few millimeters to large confluent patches.Keratoacanthomas (KAs) are considered by some to be a variant of SCC. Typically, a rapidly enlarging papule evolves into a sharply circumscribed, crateriform nodule with a keratotic core over a period of a few weeks. Most lesions occur on the head and neck.Verrucous carcinoma is considered a lowgrade malignancy with three major subtypes: (1) epithelioma cuniculatum (plantar surface of the foot); (2) giant condyloma acuminatum of the genitalia (also known as Buschke–Löwenstein tumor); and (3) oral florid papillomatosis. Clinically, verrucous carcinomas present as large (sometimes huge), exophytic tumors with a papillomatous or verrucous surface.Cutaneous horn is a clinical term for a white to yellow, hard, keratotic conical lesion whose base is a papule, plaque or nodule. Cutaneous horns may arise anywhere on the body, but favor sun-exposed sites. Bowen disease is caracterizid with erythematous well-demarcated plaques that may resemble to dermatitis or psoriasis. It may appear on skin, oral and genital mucousa and even nail bed. There are surgical and medical treatment modalities for these lesions.

کلیدواژه ها:

precancerous lesions ، clinical features ، treatment