somaye amini - Department of Horticultural Science, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
seyed mahdi ziaratnia - Department of Food Biotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran
sara malek mohammadi kakhki - Faculty of Basic Sciences, Islamic Azad university, Mashhad, Iran

World growing population, increasing trend of consumption of natural compounds and consequently collection of the wild medicinal plants in unscientific methods have led to emergence of a big challenge for human being that is endangered wild species, and decline in plant biodiversity. Therefore, sustainable production of valuable compounds in vitro conditions is essential nowadays due to making least stress on natural resources. As in vitro methods are expensive, many researchers have reported that bioreactors as instrument for scaling up the production of plant derived medicinal compounds and then reducing the cost of products. Using bioreactor caused the higher production of desired compounds in a shorter time, lower labor costs, occupying less place and continuous production. This method of production is independent to the climatic changes and soil conditions that are influence on the yield and quality of metabolites. Recently, several types of bioreactors have been designed for different purposes of plant cell and organ cultures. There are many examples of plant-derived high value molecules produced in bioreactors such as Paclitaxel, Comptothecin, Rosmarinic acid, Verbascoside, Artemisinin and Galanthamin. This review summarizes the bioreactors types and configuration, advantages and limitations on plant biomass and bioactive compounds from cell suspension, organ, Shoot, Embryo, hairy and adventitious root cultures, and strategies for enhanced production of plant secondary metabolites using bioreactors.

Cell Suspension Culture, Medicinal Plants, Organ Culture, Secondary Metabolites