The role of genetic material and yeast in reducing the effect of T2 toxin on some physiological parameters in mice

The results showed a significant increase in active the Aspartate transaminase enzyme when dosage by toxin (122 enzymatic units/L.) , compared with control group (102 units / liter). While genetic material and yeast with toxin showed significantly reduced of toxin effectiveness. The results showed increase in activity of Aspartate transaminase enzyme in animal serum when dosage by toxin 8.9 enzymatic unit / L. and 8.5 enzymatic unit / L. for control group. The genetic material and yeast as adsorbents caused a reduction in the effect of trichothecenes on Alanine transaminase activity, thus restoring normal activity. The results also of this experiment showed that the dosage of trichothecenes for laboratory animals led to a significant reduction at the level (0.05) in its active enzyme Alkaline phosphatase activity (35.5 enzyme alone/L.), compared with control group (37.1 U/L.).The results showed that added of genetic material and yeast , caused in a significant decrease in enzyme activity, compared with dosage of toxin alone or control group .The results showed that the reason for the decrease in total protein in the blood may be due to the presence of toxin, that the toxin effects on the processes that lead to the manufacture of proteins in the cell, may affect in the cloning of DNA into mRNA or may effect on some of the substances that play a role in translating mRNA into ribosomes and the factors involved in initiating the process of protein synthesis. The dosage of trichothecene with the genetic material and yeast , has caused a significant increase in the concentration of the total protein in the blood and this is due, as already pointed out to the role of these factors in the toxicity of trichothecene which leads to blocking its effect ,also the result showed that the dosage of trichothecene has significantly increased the concentration of uric acid in blood (5.2 mg / 100 ml) compared with control group 4.3 mg / 100 ml , genetic material and yeast did not significantly reduce the concentration of uric acid. While the results showed that dosage of trichothecenes a significant decrease in blood glucose concentration (172 mg / 100 ml) compared with control group (184 mg / 100 ml) , and by used genetic material and yeast caused significant increase in the concentration of blood glucose compared with used of toxin alone . The results showed (table 2) that the trichothecene caused a significant reduction in the total protein concentration in the blood, where the concentration was 4.7 mg / 100 ml with the presence of toxin compared with control group 5.9 mg / 100 ml.