Red blood cell phenotyping of patients with hemoglobinopathies or malignancy referring to Yazd Blood Transfusion Center

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 432

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شناسه ملی سند علمی:

ACPLMED18_014

تاریخ نمایه سازی: 20 آبان 1397

چکیده مقاله:

Background: More than 300 antigens have been identified on the Red Blood Cells. The blood transfusion services in resource limited countries only test for ABO and RhD antigens and cross matching. However, transfusion of ABO-RhD compatible but unknown phenotype blood may result in alloimmunization especially in multitransfused patients. The most significant red blood cell alloantibodies encountered are from the Rh, Kell, Duffy and Kidd blood group system. The typing of these blood groups is frequently undervalued and little data is available regarding the frequency of the blood group antigens other than ABO and RhD in these patients. Aims: The aim of this study was to evaluate the prevalence of ABO, Rh, Duffy, Kell, Kidd and MNSs groups among the patients referring to Yazd blood transfusion center.Material and Methods: The study was conducted at the Yazd Blood Transfusion center. Data of RBC blood grouping and phenotyping from 51 patients were collected. Forward blood grouping was performed using commercially available antisera (CE-Immunodiagnostica GmbH, Germany). Results: A total number of 51 cases was subjected to extended Rh system phenotyping (D, C, E, c and e) and to phenotyping for other blood group systems. 45 cases were RhD positive (88%) and 6 (12%) were RhD negative. The frequency of ABO blood group system was A (25.5%), B (31.3%), AB (6%) and O (37.2%). In Rh system, C antigen frequency was (72.5%), c (68.6%), E (23.5%), e (94.1%). Amongst other blood group antigens, Kell (K) antigen frequency was 0, Duffy (Fya) 82.3%, Duffy (Fyb) 70.5%, Kidd (Jka)74.5%, Kidd (Jkb) 68.6%, M 78.4%, S 70.5%, and s 72.5%. Most common phenotypes in Duffy system were Fy a+b- (27.4%), Fya+b+ (56.8%), Fy a-b+ (17.6%). Most common phenotypes in Kidd system were JK a+b+ (43.1%), JK a+b- (29.4%), JK a-b+ (25.4%). Conclusion: Current study represents the prevalence of the blood group antigens among patients referring to Yazd Blood Transfusion Center. The information about the blood group antigens prevalence can assist in the preparing phenotype matched blood components to patients to reduce the incidence of alloimmunization to blood group antigens.

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نویسندگان

Hayedeh Javadzadeh Shahshahani

Blood Transfusion Research Center, High institute for research and education in transfusion medicine, Tehran, Iran

Azam Hayati

Blood Transfusion Research Center, High institute for research and education in transfusion medicine, Tehran, Iran