nahid sadough - Department of biochemistry,Science and Research ,Islamic Azad university ,Tehran ,Iran

Introduction Schizophrenia is a mental disorder painful with prevalence of about 1% in the world . Nowadays , there is no experimental test aiding the accurate diagnosis of schizophrenic patients but recently quantitative determination of some serum lipoproteins led to many investigation on the roles of these in neuropsychiatric .In the present study our aimc is to quantitative determination ApoA1 between 134 schizophrenic patients and 127 healthy control persons. Materials and Methods Schizophrenia patients were selected from the Tehran Razi hospital . The age (p=0.53) and sex distribution of schizophrenic patients were similar to those of control persons. We measured ApoA1 by immunoturbidimetry method. Results : P<0..05 was considered significant . ApoA1 showed a significant decrease in serum ( p=0.001) (table 1). Conclusion : This results support other reports an decrease ApoaA1 confirm relationship of lipid metabolism in schizophrenia patients ,also female patients showed more metabolism dysfunction and in male patients decrease Apo A1 was higher

schizophrenia,Apo A1