Diagnostic value of immunohistochemicial staining of Galactin-3, HBME-1 and CK-19 in differentiating benign from malignant thyroid lesion

  • سال انتشار: 1391
  • محل انتشار: چهاردهمین همایش سالانه انجمن علمی آسیب شناسی ایران
  • کد COI اختصاصی: ACPLMED14_085
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 598
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نویسندگان

S.H Madani

Department of pathology, Molecular Pathology Research Center, Imam Reza University Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

K Shahebrahimi

Department of Internal medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

T Almasi

General Practitioner, Molecular Pathology Research Center, Imam Reza University Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

S Almasi

Department of Microbiology, Molecular Pathology Research Center, Imam Reza University Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

چکیده

Introduction: Cancer of thyroid is the commonest malignancy in endocrinology. The goldstandard of diagnosis of thyroid nodules is achieved through pathologic evaluation usingroutine H&E staining method. However, morphologic overlap between benign and malignantthyroid lesions, especially follicular variant of papillary carcinoma is common and in somecases, makes a consistent diagnosis impossible. Markers used for this differential diagnosisincludes HMWCK, CK19, Galactin-19, HBME-1, CD57, CD15, CD44, etc. In this study weassessed the protein expression of Galactin-3, HBME-1 and CK19 in thyroid lesions (benignvs.malignant) to evaluate their diagnostic values.Material & methods: In this study 70 paraffin blocks including 45 malignant lesion and 25benign lesions were selected from pathology laboratory of Imam Reza hospital. Appropriatesections prepared for H&E staining and also for immunohistochemical staining of threeabove-mentioned markers. Then the result assessed using SPSS (Ver. 17).Results and discussion: of 70 cases which selected, 25 are benign and including, nodulargoiter(11 cases, 15.7%), follicular adenoma (9 cases, 12.9%), Hurtle cell adenoma (4 cases,5.7%) and Hashimoto thyroiditis (2 cases, 2.9%), 45 cases are malignant and including welldifferentiatedPapillary carcinoma(30 cases, 42.8%), follicular variant of Papillary carcinoma(7 cases, 10%), tall cell variant of Papillary carcinoma (3 cases, 4.3%), diffuse sclerosingvariant of Papillary carcinoma (1cases, 1.4%), micropapilary carcinoma (1 cases, 1.4%) andHurthel cell carcinoma (1 cases, 1.4%).Immunohistochemical result reveals that three studied markers are useful for differentiatingbenign from malignant lesions of thyroid (statistically significant, P value=0.001).

کلیدواژه ها

Malignant, Thyroid, Galactin-3, HBME-1, CK-19

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