CIVILICA We Respect the Science
(ناشر تخصصی کنفرانسهای کشور / شماره مجوز انتشارات از وزارت فرهنگ و ارشاد اسلامی: ۸۹۷۱)

PRIMARY EVIDENCE ON THE POTENTIAL OF THREE IRANIAN ENDEMIC PROBIOTICS IN TREATMENT OF HEPATOCELLULAR CARCINOMA

عنوان مقاله: PRIMARY EVIDENCE ON THE POTENTIAL OF THREE IRANIAN ENDEMIC PROBIOTICS IN TREATMENT OF HEPATOCELLULAR CARCINOMA
شناسه ملی مقاله: MEDISM19_721
منتشر شده در نوزدهمین کنگره بین المللی میکروب شناسی ایران در سال 1397
مشخصات نویسندگان مقاله:

Fatemeh Karami - Department of Medical Genetics, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
Maryam Aminaee - Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Maryam Tajabadi Ebrahimi - Department of Science, Islamic Azad University, Central Branch, Tehran, Iran
Fattah Sotoudehnejad - Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

خلاصه مقاله:
Background and Aim:Hepatocellular carcinoma (HCC) is the 6th human cancer with high morbidity and mortality rate. Owing to the recent significance of anticancer effects of probiotics in various types of human cancers, current study was conducted to assay the potential of three Iranian endemic probiotics in inhibition of HCC cell growth.Methods:HepG2 cell line was treated with different concentration of supernatant isolated from L. paracasei, L. acidophilus and L. rhamnosus compared to MRL/MRS broth mediums as negative control. MTT assay was performed to assess cell viability within 24, 48 and 72 hours following treatment.Results:MTT results demonstrated significant decrease in HepG2 cells viability when treated with each of probiotics and was directly correlated with concentration of bacterial supernatant.Conclusion:Similar to the other human cancers, lactobacillus can be considered as a potential anticancer probiotics in restriction of HCC cells growth. Further studies are needed to clarify active components of three lactobacillus strains supernatant and their potential as adjuvant therapy in HCC patients treatment, as well.

کلمات کلیدی:
lactobacillus, HepG2, cell line, treatment

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/783058/