TRENDS OF ANTIMICROBIAL RESISTANCE AMONG UROPATHOGENIC ESCHERICHIA COLI ISOLATES IN RUDBAR, NORTH OF IRAN

Background and Aim: Escherichia coli (E. coli) is a clinically important pathogen, which frequently isolated from various infections, including urinary tract infections (UTIs), neonatal meningitis, blood stream infections (BSIs), gastroenteritis. Based on recent finding of global antibiotic resistance, E. coli is considered as an important cause of nosocomial and community-acquired infections and is one of the most common Extended-Spectrum Beta-Lactamases (ESBLs) producers. Antimicrobial resistance pattern evaluation among E. coli isolates is a necessary. The aims of this study were to determine the frequency and antimicrobial resistance pattern of E. coli isolates isolated from UTIs.Methods: This retrospective study done within 12 months from March 2017 to February 2018 in a Rudbar central Hospital, North of Iran. E. coli isolates were obtained from urine specimens and identified using standard microbiological procedures. Antimicrobial susceptibility patterns were determined using disk diffusion method in accordance with CLSI recommendation.Results:Of totally 792 urine cultures, 75 (9.5%) cultures showed noteworthy E. coli growth. Overall, the most of E. coli strains (80%) isolated from female specimens. The results of antibiotic susceptibility showed that the effective antibiotic for tested E. coli isolates was ciprofloxacin with 63.4% sensitivity rate, followed by nitrofurantoin (58.6%), ceftriaxone (58%) and co-trimoxazole (56%). Moreover, the lowest antibiotic susceptibility rate was seen toward cefazolin (42%).Conclusion:The results showed that fluoroquinolones was the most effective antibiotic against E. coli infections in our region. Additionally, nitrofurantoin and ceftriaxone as effective substitution of fluoroquinolones are recommended for UTIs treatment.

کلیدواژه ها:

Escherichia coli ، Urinary tract infections ، Antibiotic susceptibility