AN INVESTIGATION OF ANTIBACTERIAL ACTIVITY OF ZNO NANOPARTICLE ON STAPHYLOCOCCUS AUREUS AND E.COLI

Background and Aim:In recent years, in order to prevent excessive use of antibiotics, disinfectant agents have gained particular significance. There are several reports on the antimicrobial effect of ZnO on Gram-positive and Gram-negative bacteria and fungi. this study was conducted to evaluate the antibacterial effects of zinc oxide nanoparticles in vitro.Methods:In this study, minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) of this substance were determined using standard liquid dilution and disk diffusion methods for Gram-positive strain (S. aureus) and Gram-negative strain (E. coli) have calculated according to. Data analysis was performed using oneway ANOVA and Duncan tests at the level of p<0/05.Results:According to the results of this study, MBC values of ZnO nanoparticle for S. aureus and E. coli bacteria were calculated to be 0.095 and 0.8µg/ml, respectively, and MIC values for S. aureus and E. coli were calculated 0.09, 0.095µg/ml, respectively.Conclusion:Our study indicates that zinc oxide nanoparticles could potentially be an antibacterial reagent to treat diseases caused by S. aureus and E.coli.

کلیدواژه ها:

Zinc oxide ، nanoparticle ، Staphylococcus aureus ، Escherichia coli ، antibacterial activity