ANTIMICROBIAL EFFECTS OF ETHANOL EXTRACTS OF PLANTS MEDICAGO SATIVA AND ECHINOPHORA PLATYLOBA D.C ON ENTEROCOCCUS FAECALIS BACTERIA IN VITRO

Background and Aim:Since drug resistance has become a global health problem, new methods to fight these resistant bacteria are needed. One of the ways to cope with these resistance is through the use of herbs and their derivatives. This study was designed to determine the antimicrobial efficacy of the hydroalcoholic extracts of Medicago sativa and Echinophora platyloba D.C against Enterococcus faecalis bacteria in vitro.Methods:hydro alcoholic extract of two medicinal plants collected from The scope of Chaharmahal va Bakhtiari; the hydroalcoholic extracts of the plants were prepared by maceration then The MIC values and MBC of the Medicago sativa and Echinophora platyloba D.C extract against E.fecalis ATCC 29212 were determined by a micro broth dilution method based on instructions CLSIResults:The MIC value for the hydro alcoholic extract of Medicago sativa was 512 μg/mL for E.fecalis and The MIC value for the hydro alcoholic extract of Echinophora platyloba D.C was 32 μg/mL also The MBC value of the ethanol extract of Medicago sativa was 1024 μg/ml for E.fecalis and The MBC value of the ethanol extract of Echinophora platyloba D.C was 128 μg /mlConclusion:The findings of the study showed that the most antibacterial effect on E.fecalis is related to Echinophora platyloba D.C And the lowest microbial activity against this bacterium is Medicago sativa. the necessity of further research on this plant in order to extract its effective compounds and its effects on a variety of pathogens is suggested.

کلیدواژه ها:

Antimicrobial effects ، Medicago sativa ، Echinophora platyloba D.C ، Enterococcus faecalis