ANTIFUNGAL EFFECT OF ALLIUM CEPA ETHANOLIC EXTRACT AGAINST TRICHOPYTON RUBRUM
محل انتشار: نوزدهمین کنگره بین المللی میکروب شناسی ایران
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 524
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شناسه ملی سند علمی:
MEDISM19_154
تاریخ نمایه سازی: 13 مهر 1397
چکیده مقاله:
Background and Aim:Dermatophytosis is one of the most common superficial fungal infections worldwide. Trichophyton rubrum is one of the most common of dermatophytes that caused variety of clinical forms. Due to the recurrence of recurrent infections due to the resistance of the organism to the drug and the side effects of prolonged use of anti-inflammatory drugs, including long-term therapeutic strategies the aim of this study was to investigate the effect of ethanolic extract of Alium cepa (AEC) on T.rubrum growth.Methods:The inhibitory effect of (ACE) extract against T. rubrum was assessed by broth microdilution (CLSI, M-38) methods in comparing with terbinafine.Results:The results showed that the minimum inhibitory concentration (MIC) of ACE and terbinafin for fungi growth was 1.46 and 1µg/ml and MIC 50 for these compounds was 0.73and 0.5 µg/m l, respectively.Conclusion:The results of this study showed that ACE is an effective factor that inhibit Thrichophyton rubrum growth and can be considered as a target for antifungal design methodology.
کلیدواژه ها:
نویسندگان
Zeynab Mosazadeh
Department of Mycology, Tarbiat Modares University, Iran
Masoomeh Shams-Ghahfarokhi
Department of Mycology, Tarbiat Modares University, Iran
Mehdi Razzaghi-Abyaneh
Department of Mycology Pasteur Institute, Iran