Mohammad Mehdi Attarpour Yazdi - Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran

Background and Aim:Background: Escherichia coli (E.coli) are an important pathogen in the Urinary Tract Infection (UTI). Increasing of antibiotic usage for E.coli infections, created antibiotic resistance. Medical herbs with anti-microbial activity have always been important role in traditional medicine. The purpose of this study was to determine the antibacterial activity of ethanolic extract of Cinnamomum zeylanicum against E.coli isolated from UTI in vitro.Methods:Methods: This research is a descriptive analytic study. First, samples of ethanolic extract of Cinnamomum zeylanicum were prepare by maceration method. Then its antibacterial activity against 75 isolates of E.coli from 100 samples of UTI was evaluated by well diffusion and then agar serial dilution method. Also, the MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) of extract was determined. Also the antibacterial activity of 11 antibiotics such as chloramphenicol, trimethoprim, streptomycin, gentamicin, erythromycin, doxycycline, nalidixic acid, and est. was tested by the disk diffusion method.Results:Results: The diagrams, T- test were used to compare the results. The results demonstrated that the ethanolic extracts of Cinnamomum zeylanicum show an average inhibitory zone diameter of 17mm. The ethanolic extract shows best result having ZOI greater than that of the selective antibiotics. There was no significant difference between the effects of the plant ethanolic extract and the antibiotics on E.coli (P> 0.05).Conclusion:Conclusion: This study demonstrates that an ethanolic extract of Cinnamomum zeylanicum have antibacterial activity against E.coli isolated from UTI and its effect is similar selective antibiotic. Further investigations will be necessary.

UTI, Escherichia coli, Cinnamomum zeylanicum, Antibacterial Activity