Vahid Moghaddam - Deprtment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Maghsoud Peeri - Deprtment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Mohammad Ali Azarbayjani - Deprtment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Hasan matin Homaee - Deprtment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Introduction: The aim of this study was to compare the protective effects of two typesof aerobic and intermittent training on breast cancer as a result of TGFβ protein, Smad-3,and MMP2 gene in female mice.Methods: In the experimental study, a total of 24 female BALB/c mice afterTumorigenesis by MC4-L2 cell line in the three groups; Control, Aerobic, andIntermittent training groups, and under standard conditions were studied. Aerobiccontinuous training group performed 60 minutes of running on a treadmill with intensityof 60-65% VO2max, 5 days a week and high-intensity intermittent program included sixbouts alternates (3 minutes and 20 seconds with intensity of 85–90%VO2max and aminute of recovery with intense 30-35%VO2max between each alternate) for a period of10 weeks. Data using one-way ANOVA and Tukey s test at a significance level ofP<0.05 were analyzed.Results: High-intensity intermittent training significantly increased expression of Smad-3(P<0.03), and protein TGF-β (P<0.000) and decreased the expression of MMP-2(P<0.000) in tumor tissue than in the control group. Aerobic training also significantlyincreased the expression of Smad-3 (P<0.03) and protein TGF-β (P<0.000) and decreasedthe expression of MMP-2 (P<0.04) in tumor tissue than in the control group. Nosignificant differences in gene expression Smad-3 and MMP-2 between training groups wasobserved (P<0.05), However, there was significant differences in the TGF-β proteinbetween High-intensity intermittent training and aerobic training groups (P<0.05).Conclusion: It seems that high-intensity intermittent and aerobic continuous training canpossibly be effective interventions to reduce breast cancer progression and there is notmuch difference between the effects of two types of training.

Breast Cancer, Training, TGFβ, Smad, MMP2