Microwave-assisted synthesis of 5,10,15,20-tetrakis(4- nitrophenyl)porphyrin and zinc derivative and study of their bacterial photoinactivation

In this study, 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) and its zinc porphyrincomplex (ZnTNPP) were synthesized in situ using the microwave method and identified by UVVis,FT-IR and 1H NMR. The photostability and photodynamic antimicrobial activity (PACT) ofthese compounds were investigated on Pseudomonas aeruginosa and Bacillus subtilis undervisible light irradiation. MIC, MBC and inhibition zones produced by these compounds weredetermined and the number of bacteria counted. The results indicated that both compounds havesignificant stability when illuminated for various illumination periods in nutrient broth media.Both compounds exhibited more effective activity against P. aeruginosa than B. subtilis innutrient agar.

کلیدواژه ها:

Antimicrobial activity ، Bacillus subtilis ، Photoinactivation ، Pseudomonas aeruginosa ، TNPP