MiRNAs profiling as diagnostic biomarkers for epilepsy
- سال انتشار: 1396
- محل انتشار: دومین کنگره بین المللی و دهمین همایش ملی نوروژنتیک ایران
- کد COI اختصاصی: NGCMED10_187
- زبان مقاله: انگلیسی
- تعداد مشاهده: 412
نویسندگان
Department of Medical Genetics, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran- Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran- Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
چکیده
Introduction: Epilepsy is a chronic neurologic disorder determined by recurrent unprovoked seizures due toabnormal neuronal excitability. MicroRNAs are a family of small non-coding RNAs that control geneexpression. Recent investigations have confirmed the importance use of specific miRNAs as key regulatorymechanisms and therapeutic targets in epilepsy. So the purpose of this study was to identify and validatemicroRNAs as biomarkers in the diagnosis of epilepsy.Method: We searched about this subjects in Google Scholars, Web of Sciences, PubMed and Scopus then foundmore than 10 articles related to our subject and we explained them in the results.Result: The studies showed a lot of microRNAs that differentially expressed in different stages of epilepsycompared with healthy controls.The studies confirmed the significantly upregulation of miR-132, miR-212 in the plasma of patients. MiR-21 ormiR-132 have been found to be overexpressed in human TLE(temporal lobe epilepsy) when determinedindividually. Also, Ashhab et al. represented that both miR-221 and miR-222 were downregulated in the threephases of TLE in children with epilepsy. Dr. Gorter and colleagues showed the upregulation of miR-146aexpression in plasma appeared comparatively later in the chronic phase, while miR-142 was enhanced during theacute phase.The other articles indicate the dysregulation of 3 miRNAs (miR-333, -685 and -298) at 24h after KA-induced SEin whole-blood, so this miRNAs can be considered to be used as diagnostic biomarkers for epilepsy.Conclusion: Based on the articles, microRNAs might be targeted to prevent or disrupt epilepsy as well as serveas diagnostic biomarkers of epileptogenesis.کلیدواژه ها
miRNA, epilepsy, biomarkerاطلاعات بیشتر در مورد COI
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