Genotoxicity and cytotoxicity of mineral trioxide aggregate and calcium enriched mixture cements on L929 mouse fibroblast cells
عنوان مقاله: Genotoxicity and cytotoxicity of mineral trioxide aggregate and calcium enriched mixture cements on L929 mouse fibroblast cells
شناسه ملی مقاله: NGCMED10_116
منتشر شده در دومین کنگره بین المللی و دهمین همایش ملی نوروژنتیک ایران در سال 1396
شناسه ملی مقاله: NGCMED10_116
منتشر شده در دومین کنگره بین المللی و دهمین همایش ملی نوروژنتیک ایران در سال 1396
مشخصات نویسندگان مقاله:
Mohaddeseh Sadat Alavi - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sahar Fanoudi - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hamid.R Sadeghnia - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
خلاصه مقاله:
Mohaddeseh Sadat Alavi - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sahar Fanoudi - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hamid.R Sadeghnia - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Introduction: Mineral trioxide aggregate (MTA) has shown good biocompatibility in several studies.Methods: In the present study, the genotoxic and cytotoxic effects of calcium enriched mixture (CEM) wereevaluated compared with MTA using MTT and single-cell gel (comet) assays with serial ascendingconcentrations (0 to 1000 μg/mL) of tested materials.Results: Cytotoxicity data indicated that there is no significant difference between CEM and MTA at allconcentrations except for the full concentration (1000 μg/mL); CEM had lower cytotoxicity. Genotoxic effectswere more evident with CEM at concentrations of 15.6 and 250 μg/mL; however, was less than that of MTA atconcentrations of 500 and 1000 μg/mL. The cytotoxicity and genotoxicity effects of the two experimental groupsgenerally increased with consistency.Conclusion: Under the conditions of this study, CEM is biocompatible in terms of cyto- and genotoxicity. Itappears to be an alternative to MTA as an endodontic biomaterial offering several advantages.
کلمات کلیدی: Biocompatible, Calcium Enriched Mixture, Cytotoxicity, Genotoxicity, Mineral Ttrioxide Aggregate
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/744964/