Genotoxicity and cytotoxicity of mineral trioxide aggregate and calcium enriched mixture cements on L929 mouse fibroblast cells
- سال انتشار: 1396
- محل انتشار: دومین کنگره بین المللی و دهمین همایش ملی نوروژنتیک ایران
- کد COI اختصاصی: NGCMED10_116
- زبان مقاله: انگلیسی
- تعداد مشاهده: 410
نویسندگان
Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: Mineral trioxide aggregate (MTA) has shown good biocompatibility in several studies.Methods: In the present study, the genotoxic and cytotoxic effects of calcium enriched mixture (CEM) wereevaluated compared with MTA using MTT and single-cell gel (comet) assays with serial ascendingconcentrations (0 to 1000 μg/mL) of tested materials.Results: Cytotoxicity data indicated that there is no significant difference between CEM and MTA at allconcentrations except for the full concentration (1000 μg/mL); CEM had lower cytotoxicity. Genotoxic effectswere more evident with CEM at concentrations of 15.6 and 250 μg/mL; however, was less than that of MTA atconcentrations of 500 and 1000 μg/mL. The cytotoxicity and genotoxicity effects of the two experimental groupsgenerally increased with consistency.Conclusion: Under the conditions of this study, CEM is biocompatible in terms of cyto- and genotoxicity. Itappears to be an alternative to MTA as an endodontic biomaterial offering several advantages.کلیدواژه ها
Biocompatible, Calcium Enriched Mixture, Cytotoxicity, Genotoxicity, Mineral Ttrioxide Aggregateاطلاعات بیشتر در مورد COI
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