MTHFR 677C> T Polymorphism and Male Infertility Risk: A Meta-Analysis
- سال انتشار: 1396
- محل انتشار: دومین کنگره بین المللی و دهمین همایش ملی نوروژنتیک ایران
- کد COI اختصاصی: NGCMED10_041
- زبان مقاله: انگلیسی
- تعداد مشاهده: 452
نویسندگان
Student Research Committee, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences,Mashhad, Iran
Department of environmental health, School of heath, Gonabad University of Medical Sciences, Gonabad, Iran
چکیده
Background and Objectives: MTHFR polymorphism may be a risk factor for male infertility. However, the resultsfrom studies presented conflicting results regarding MTHFR polymorphism and the risk of male infertility.Therefore, we performed a meta-analysis of case-control studies to re-examine the controversy.Methods: The databases of PubMed, Scopus, Cochrane, Google Scholar, SID, IranMedex and Magiran until July2016 and reference section of relevant articles, were searched to identify both English and Persian case-control studieson male fertility issue that observed the association between MTHFR polymorphism and male infertility risk andtheirs quality was evaluated by Newcastle-Ottawa Scale (NOS)checklist. A total of 28 trials were finally included.Crude odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of association between theMTHFR polymorphism and male infertility risk.Results: MTHFR 677C> T polymorphism indicated significant associations with male infertility risk in both fixedeffects (CT+TT vs. CC: OR = 1.36, 95% CI: 1.24–1.47) and random effects models (CT+TT vs. CC: OR = 1.38,95% CI: 1.20–1.54). Additional, when we analyzed by Asians Caucasians, Azoo or OAT subgroup, the similarresults were observed.Conclusions: Our results showed that the MTHFR polymorphism is related to an increased risk of male infertility.Additional well-designed analytical studies are needed to confirm our results and assess gene-environmentinteractions with male infertility risk.کلیدواژه ها
MTHFR, Polymorphism, Male infertilityمقالات مرتبط جدید
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