Platelet rich plasma promotes neuronal repair in a rat model of spinal cord injury

Many pathological events occur after spinal cord injury (SCI). A diversity ofmolecular/cellular pathways are likely involved in the underlying pathologiesof SCI. Recently, there is great interest for utilizing of platelet-rich plasma(PRP) in regeneration of peripheral nerve. There is no literature on the effectof PRP on the regeneration of central nerve fibers particularly SCI. The aim ofpresent study was to evaluate the effect of PRP on the repair of spinal cordinjury in rat model. Rats were randomly divided into three groups with sixrats in each group. Then, spinal cord injury was performed under generalanesthesia using weight dropping method. Group one included ratsreceiving normal saline, group two received PRP one week after injury; groupthree received PRP 24 h after injury. Three week after injury, biotin dextranamine (BDA) was injected intra cerebral and in fifth week, tissue staining wasperformed. Numbers of BDA-labeled axons in groups two and threestatistically different from control group. Also,results showed that there werea significant difference between groupthree and control in functionalrecovery. Our findings suggest that PRP can be used as effective treatment inSCI. the present study is the first report that PRP could improve central nerverecovery after SCI.

کلیدواژه ها:

Spinal Cord Injury ، Platelet Rich Plasma ، Functional Recovery ، Neuronal Repair