Elham Yousefian - Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences Isfahan, Iran
Azra Allahveisi - Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sannandaj, Iran

Background: Maternal thrombophilia is the main risk factor for recurrent pregnancy loss (RPL). In these conditions, fetal death may happen due to low placental perfusion caused by maternal thrombophilia. The aim of this study was to evaluate the Prothrombin G20210A mutation in cases with history of RPL. Material and methods: A total of 366 cases, 250 with diagnosis of RPl and 116 control cases, were included in this controlled study. In all cases, Prothrombin 20210A mutation analysis was carried out by means of Polymerase Chain Reaction (PCR) -Reverse hybridization technique. Results: The frequencies of heterozygous mutation prothrombin G20210A were 6% and 0.9%, respectively (P = 0.025), in cases compared to the control group. The frequencies of homozygous mutation prothrombin G20210A were 0.4% and 0%, respectively, in cases compared to controls (P = 0.02). The prothrombin mutation was significantly higher in cases compared to the control group (odds ratio 8.81; 95% confidence interval: 1.16–66.62).Conclusion: Our study found a significant higher frequency of prothrombin G20210A in women with RPL in comparison with controls. This study suggest that the prothrombin G20210A mutation, may be an unrecognized cause of RPL in our population.