GCSF May Improve Pregnancy Outcome in Blastocyst Embryo Transfer Patients With History of Unexplained Implantation Failure And Normal Endometrium. A Randomized Control Trial
محل انتشار: چهارمین کنگره بین المللی تولیدمثل
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 597
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شناسه ملی سند علمی:
ISERB04_171
تاریخ نمایه سازی: 16 تیر 1397
چکیده مقاله:
Background: family of colony-stimulating factors (CSF) plays a pivotal role in the early dialogue between mother and embryo. Objective: the aim of this study was to evaluate the effects of the single dose G-CSF injection in unexplained group of patients with repeated implantation failures with normal endometrium in whom embryo transfer has been done in blastocyst stage. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the historyof more than three previous IVF/ICSI-ET failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 μg (0.5ml) recombinant human GCSF subcutaneously injected 30 minutes before blastocyst embryo transfer. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS), version 16.0 Results: G-CSF treated group showed higher clinical pregnancy rate (56.2%) in comparison with control group (40.0%) but it was not statistically significant (P=0.09, chi-square). Although the rate of live birth rate in G-CSF group was higher than control group (53.1% vs35.0%) but there was positive but not statistically significant difference in the overall live birth rate between the two groups (P=0.10, t-test). Conclusions: Our result demonstrates that pregnancy outcome was better in women with repeated IVF failure who are treated with G-CSF
کلیدواژه ها:
نویسندگان
Soheila Arefi
Genetics & In Vitro Assisted Reproductive (GIVAR) center, Erfan hospital,
Elham Fazeli
Department of Anatomy and Reproductive Biology, School of Medicine, Shahid Beheshti University of Medical Sciences
Manijeh Esfahani
Department of Anatomy and Reproductive Biology, School of Medicine, Shahid Beheshti University of Medical Sciences
Nasim Borhani
School of Medicine, Shahroud University of Medical Sciences