Synergistic Effects Of Sulpride And SCH23390 On Kiss1 Gene Expressions In L-Dopa Treated PCOS Rats

ground: Polycystic ovary syndrome (PCOS)is an important cause of anovulation in women. Kisspeptin is a hypothalamic neuropeptide and it exerts stimulatory effects on gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion. Dopamine inhibits kisspeptin synthesis and its release is lower in PCOS women compared to healthy individuals. In the present study the effects of L-dopa and dopamine receptor antagonists were investigated on relative KiSS1 gene expressions in the hypothalamus of PCOS model rats. Methods: Polycystic ovary syndrome was induced by intramuscular injections of estradiol valerate in fifteen rats. The PCOS rats in three groups received saline, L-dopa (100mg/kg), simultaneous injections of sulpride (10mg/kg), SCH23390 hydrochloride (1mg/kg) and L-dopa (100mg/kg) via intraperitoneal injection respectively. Also, five intact estrous rats as a control group received saline intraperitoneally. Hypothalamic samples were dissected. Mean 

کلیدواژه ها:

sulpride ، SCH23390 ، KiSS1 ، PCOS