Investigating the relationship between ApaI polymorphism of vitamin D receptor gene (VDR) and the risk of breast cancer in central Markazi women

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 425

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شناسه ملی سند علمی:

ICBCMED13_192

تاریخ نمایه سازی: 2 تیر 1397

چکیده مقاله:

Introduction: Vitamin D plays a major role in cell proliferation, apoptosis, suppresses tumor growth. Vitamin D receptor is a vital mediator for the cellular effects vitamin D. A series of epidemiologic studies have examined the association between ApaI polymorphism of the VDR gene and breast cancer, but conflicting findings have been obtained. Materials and Method: In this study, the effects of vitamin D receptor ApaI polymorphism and risk of breast cancer in a large population based on a case-control study of 125 patients and 135 healthy women from the women of Markazi province were evaluated.Results: The ApaI polymorphism of the VDR gene was evaluated by PCR-RFLP analysis in patients with breast and healthy breast cancer. According to the findings, no significant correlation was found between genotypes of ApaI polymorphism and VDR gene and breast cancer (0.9302; CI = 95%, OR =0.29-2.95).Conclusion: In our study, these findings showed that C allele of the VDR group did not have any risk for breast cancer compared to the control group.

نویسندگان

Mahsa mohammadi

MSc student in genetics, Department of Biology, University of Arak, Arak, Iran

Jamshid Ansari

Assistant Professor of Department of Encology, Ayatollah KHANSARI Hospital, University of Medical Sciences, Arak, Iran

Ahmad Hamta

Assistant Professor of Department of Biology University of Arak, Arak, Iran.