The Relationship between Intake of Macronutrients and Vitamins Involved in One Carbon Metabolism with Breast Cancer Risk in Iranian women

Background: Breast cancer is the most common cancer among females in the world. Identifying the nutrients that modify the risk of the disease is one of the key strategies for improving the quality of life and reducing treatment costs. This study aimed in investigation of the relationship between the intake of macronutrients and vitamins involved in one carbon metabolism with breast cancer risk. Methods: Demographic data, physical activity level and nutrients’ intake from diet and supplements were collectedthrough interview from 151 cases and 154 controls. Dietary intake was assessed by a valid and reliable 168-item semiquantitative food frequency questionnaire. The relationship between dietary and/or supplemental intake of studied nutrients and risk of breast cancer was determined using logistic regression test. Results: After modifying the effects of confounding variables, the risk of breast cancer was significantly lower in the highest intake quartile category relative to the lowest quartile category for total protein (OR= 0.16, 95%CI=0.06–0.44; Ptrend<0.001 ) and total fiber (OR= 0.12, 95% CI=0.05–0.28; Ptrend<0.001 ), dietary and total intake of vitamin B2 (OR= 0.14, 5%CI=0.06–0.34; Ptrend<0.001) and (OR= 0.17, 95%CI=0.07–0.39; Ptrend<0.001), vitamin B6 (OR= 0.08, 95%CI=0.03–0.21; Ptrend<0.001 ) and (OR= 0.11, 95%CI=0.05–0.27; Ptrend<0.001), vitamin B12 (OR= 0.31, 95%CI=0.15–0.65; Ptrend=0.002) and (OR= 0.20, 95%CI=0.09–0.43; Ptrend<0.001) and folate (OR= 0.09, 95%CI=0.04– 0.22; Ptrend<0.001) and (OR= 0.09, 95%CI=0.04–0.21; Ptrend<0.001 ). Conclusion: The results showed that intake of protein, fiber, vitamins B2, B6, B12 and folate are associated with lower risk of breast cancer

کلیدواژه ها:

Breast Cancer ، Macronutrients ، Vitamins ، Metabolism