The association between Index of Nutritional Quality (INQ) and Breast Cancer and evaluation of nutrient intakes of these patients: A Case-Control study

Objective: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk of BrCa is 1 in 35 and each year, 8000 new cases have been made with the BrCa diagnosis. Studies have shown that dietary components are implicated in the etiology of BrCa. The INQ is a method of quantitative and qualitative analysis of single foods, meals, and diets. Methods: We examined the ability of INQs to predict the risk of BrCa in a case-control study conducted from March 2015 to February 2016. This included 145 cases and 148 controls, who attended the Shahid Beheshti University of Medical Sciences Cancer Research Center. INQ scores were computed based on dietary intake assessed using a validate 168-item FFQ. Logistic regression models were used to estimate multivariable ORs adjusted BMI, education, employment, marital status, menarche age, childbirth number, smoking, menopause status and physical activity. Results: Results obtained from modeling vitamin A, C, B1, B2 and B12 and selenium INQs as a continuous variable in relation to risk of BrCa showed a significant association after multivariate adjustment (ORvitA=0.41 [0.27-0.64]; ORvitC=0.30 [0.20-0.47]; ORvitB1=0.08 [0.04-0.17]; ORvitB2=0.19 [0.11-0.34]; ORvitB12=0.44 [0.31-0.61]; and Selenium=0.42 [0.26-0.67]). Conclusion: Subjects who consumed a more healthy diet including vitamin A, Beta-carotene, vitamin C, folate and low fat milk were at decreased risk of BrCa compared to those who consumed a more unhealthy diet including high fat and lamb meat.

کلیدواژه ها:

Breast Cancer ، Index of Nutritional Quality (INQ) ، Nutritional Assessment ، Vitamin A ، Vitamin B1 ، Vitamin B2 ، Healthy Diet