Predictive role of CD3, CD4, CD8, CD20 to neoadjuvant chemotherapy response in triple negative breast cancer patients
- سال انتشار: 1394
- محل انتشار: دوازدهمین کنگره بین المللی سرطان پستان
- کد COI اختصاصی: ICBCMED12_150
- زبان مقاله: انگلیسی
- تعداد مشاهده: 434
نویسندگان
Department of Hematology-Oncology, Iran University of Medical Sciences, Tehran, Iran.
Department of Hematology-Oncology, Iran University of Medical Sciences, Tehran, Iran.
Department of Medical Genetic, Medical Biotechnology Ins., National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
Cancer Pharmacogenetics Research Group (CPGRG), Iran University of Medical Sciences, Tehran, Iran
چکیده
Introduction & Aim: Tumor-infiltrating lymphocytes in breast cancer have been proposed as a new marker in the diagnosis of the patient s immune response. This study was aimed to determine predictive in response to neoadjuvant chemotherapy in patients with triple negative breast cancer. Methods: A cross-sectional study was done in 40 patients with breast cancer was referred to Cancer Institute, Imam Khomeini Hospital, Tehran, in April,2014 to April, 2016.T lymphocyte subtypes included CD3, CD4, CD8, CD20 and androgen receptor were investigated by Immunohistochemistry analysis pre and post-surgery. Pathologic complete response after surgery was determine Results: 22 patients were in Stage II and 18 patients were in Stage III. 13 patients had low levels of TILs and 27 patients had high levels of TILs. Six patients were positive in androgen receptor (AR).15 cases had a complete pathologic response. In the CD8-negative group, the most patients with low-levels of TILs had no complete pathological response but the most patients with high-levels of TILs had complete pathological response. In patients with CD20 positive had no impact on the patient s pathological response in terms ofthe TILs level, although, in the Absence and Mild level, the most pathological responses (80%) were negative and in the Moderate level, all pathological responses were positive. Conclusion: The findings of the study showed that Tumor-infiltrating lymphocytes can predict response to chemotherapy in patients with triple negative breast cancer after neoadjuvant therapy. Also, age, CD4 and CD8 indicators had predictive value to complete pathologic response based on TILs levelsکلیدواژه ها
Breast cancer, triple negative, lymphocytic infiltration, complete pathologic responseاطلاعات بیشتر در مورد COI
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