Construction of a sensitive electrochemical sensor for determination of anticancer drug dacarbazine using electroreduced graphene oxide as a modifier

سال انتشار: 1396
محل انتشار: پنجمین کنفرانس بین المللی نوآوری های اخیر در شیمی و مهندسی شیمی
کد COI اختصاصی: CHCONF05_394
زبان مقاله: انگلیسی
تعداد مشاهده: 329

نویسندگان

Department of Mechanical Engineering, Shohadaye Hoveizeh University of Technology, Susangerd, Iran

چکیده

A novel, simple and sensitive sensor based on carbon paste electrode (CPE) modified by electroreduced graphene oxide (ERGO) was developed for the electrochemical determination of dacarbazine (Dac). The electrooxidation of Dac was studied on modified carbon paste electrode using cyclic voltammetry and differential pulse voltammetry as diagnostic techniques. It was found that the oxidation peak current of Dac on the modified carbon paste electrode was greatly improved compared to that obtained on the unmodified carbon paste electrode. The electronic transfer property of the modified carbon paste electrode was characterized by electrochemical impedance spectroscopy (EIS). Also, morphology of modifier were characterized by scanning electron microscopy (SEM). Under optimized conditions, the modified electrode exhibited a linear response over two linear concentration ranges from 0.1 to 2000 nM Dac, with a detection limit of 0.03 nM. The proposed sensor was successfully applied for monitoring of Dac in the different real samples and satisfactory results were obtained.

کلیدواژه ها

Dacarbazine (Dac); Reduced graphene oxide; carbon paste electrode; cyclic voltammetry (CV); Differential pulse voltammetry (DPV)

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.