the effect of zolpidem on spermatogenesis of adult NMRI mouse strain

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 587

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شناسه ملی سند علمی:

ISERB03_403

تاریخ نمایه سازی: 11 خرداد 1397

چکیده مقاله:

Background: Zolpidem (with the brand name of Ambien) is a non-benzodiazepine hypnotic which binds to the benzodiazepine binding site on the GABA-A receptors.The aim of this study was to assess the effect of zolpidem on reproductive system of male adult NMRI mouse strain.Methods: In this experimental study, thirty adult female NMRI mouse strains at a mean weight of 30±26 grams were divided into five groups. Zolpidem solution was prepared in distilled water at 5, 10, and 20 (mg/kg of body mass) doses, and 0.5 cc injections were done intraperitoneally every day for 14 days. The control group received no injection. The sham group received distilled water (as solvent of zolpidem) and treatment groups of 1, 2, and 3 received doses of 5, 10, and 20 mg/kg. The treatment groups were sacrificed one day after the last injection, ,and the texture of their right and left testis tissue was separated and examined after the process of alcohol supply, molding, shredding as well as Hematoxylin and eosin painting and the results were evaluated via the tukey-test, ANOVA by SPSS program.Result: The result of section showed significant decrease in number of spermatocytes, spermatids, sertoli cells and also diameter of seminiferous on testes of the mice decreased. Also, these compounds showed a significant decrease in number of lydig cells in the experimental groups compared to the sham and control (p Conclusion: In summary, results of the current study show that injection of zolpidem was significantly effective on spermatogenesis and testis tissue.

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نویسندگان

Samaneh Mohammadian Kondori

Department of Biology, Science and Research Branch, Islamic Azad University ,Tehran, Iran

nasim Hayati Roodbari

Department of Biology,Science and Research Branch,Islamic Azad University ,Tehran, Iran

kazem Parivar

Department of Biology,Science and Research Branch,Islamic Azad University ,Tehran, Iran

Mohammad Reza salimi

department of Biology,Science and Research Branch,Islamic Azad University ,Tehran, Iran