Genetic Factor’s in ART Failure, Rif, Abortion of Laleh Hospital Infertile Patients

Background: Nowadays, role of genetic factors which previously were known as unknown causes of ART failures, RIF, Abortion, is very well understood. Men & women & embryonic chromosomal & genetic defects are significantly efficient in Fertilization potential, Cleavage potential, Blastocyst formation potential, implantation potential and abortion potential.Methods: Male factors; could be evaluated to find spermatogenesis, embryo development & 2 pre nucleuses reprogramming failures, HR Karyotyping, Sperm DNA Fragmentation & Chromatin Assay, Y Chromosomes micro deletion AZF, gr gr, CFTR, epigenetic defects, structural & numerical abnormalities of chromosomes & other genetic test.. Female factors; could be evaluated to find ovugenesis, fertilization potential, embryo formation, pregnancy potential, abortion potential, HR Karyotyping for chromosomal level of abnormalities and also: Thrombosis panel (F II Prothrombin, F V Leiden, MTHFR 1298-677, F XIII, Beta Fibrinogen, Pai1 & others), VDR, FLHR, FSHR, FMR1 & others for ovulation. In addition, viral & non viral infection pathogens must be evaluated by molecular techniques based on its detection limit, accuracy, speed & cost effectiveness to prevent their possible risk for fertilization, implantation & pregnancy lost.Result: Today’s, personalized medicine is shining as the future of medicine and soon or late we must adjust our health & especially ART centers with this novel concept. Starting ART cycles after prepare medical & genetic counseling will increase the success rate & decrease the chance of abortion & abnormalities for babies resulting from ART. In Medical Genetics & Molecular Diagnosis center’s of Laleh Hospital we are representing specialized genetic counseling for infertile couples & those who have abortion & family history for congenital & genetic disorders. This study will show 4 years valuable results & foundlings in more than 100 couple & families.Conclusion: We have found effective result for couples starting their ART cycles after genetic counselling & testing specially those who have more than one unsuccessful art cycles.

کلیدواژه ها:

Abortion ، ART Failure ، Chromosomes ، Personalized Medicine ، RIF ، SDFA ، Thrombosis ، Genetic Counselling