How Nano-micelle curcumin regresses ovarian redox system
- سال انتشار: 1396
- محل انتشار: سومین کنگره بین‌المللی تولیدمثل
- کد COI اختصاصی: ISERB03_344
- زبان مقاله: انگلیسی
- تعداد مشاهده: 429
نویسندگان
Department of Biology, faculty of Basic Science, Urmia University, Urmia, Iran
Department of Biology, faculty of Basic Science, Urmia University, Urmia, Iran
Department of Comparative histology & Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Anatomy & Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Background: Curcumin as an antioxidant component possesses a wide range of medical characteristics. Considering contrary finding about detrimental/beneficial impacts of curcumin on male and female reproductive potential, here in present study the effect of Nano-micelle Curcumin (NMC), as more active agent, on expression of antioxidant genes was assessed.Methods: To follow-up this study, twenty-four mature female Wistar rats were assigned into control and test groups. The animals in test group were subdivided into 7.5 mg/kg b.w -1, 15 mg/kg b.w -1, 30 mg/kg b.w -1NMC-received groups. The NMC was administrated orally by gavage for 48 days. Due to experimental study the animals were selected at ovulation stage by using pap-smear test and the expression of redox antioxidant genes including Mn-superoxide dismutase (SOD), CuZn-SOD and glutathione peroxidase (GSH-Px) was examined.Result: The CuZn-SOD mRNA level was increased in 15 mg/kg b.w -1 and the animals in 30 mg/kg b.w -1 NMC-received group exhibited similar pattern with control group for Mn-SOD mRNA level. The animals in 15 mg/kg b.w -1 showed enhanced GSH-Px expression versus other groups. Finally, no GSH-Px as well as SOD subtypes were determined in those animals in 7.5 mg/kg b.w -1 NMC-received group.Conclusion: Our data showed that, the NMC significantly affects the ovarian redox enzymes expression in intact female rats. More studies are needed to show the NMC-induced side effects against ovarian antioxidant potential.کلیدواژه ها
CuZn-superoxide dismutase, Glutathione peroxidase, Mn-superoxide dismutase., Ovarian tissue, Nano-micelle Curcuminاطلاعات بیشتر در مورد COI
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