Influence of unilateral orchidectomy on contralateral testis in rat, prepubertal and postpubertal
- سال انتشار: 1396
- محل انتشار: سومین کنگره بین‌المللی تولیدمثل
- کد COI اختصاصی: ISERB03_336
- زبان مقاله: انگلیسی
- تعداد مشاهده: 403
نویسندگان
Department of Urology, Mashhad University of Medical Sciences, Mashhad, IRAN
Mashhad University of Medical Sciences, Mashhad, IRAN
Department of Urology, Mashhad University of Medical Sciences, Mashhad, IRAN
Department of Urology, Faculty of Medicine Endoscopic & Minimally Invasive Surgery Research University of Medical Sciences, Mashhad, IRAN
چکیده
Background: The present study was conducted to investigate the influence of unilateral orchidectomy and age of orchidectomy on the subsequent contralateral testis.Methods: 64 Wistar-derived male rats divided randomly in 4 groups. Group 1 named immature intervention, group 2 immature control, group 3 mature intervention and group 4 mature control. In group 1, rats castrated unilateral at 30 days of age (prepubertal). In group 2 sham surgery (midscrotal incision) was done at same age. In group 3 rats castrated unilateral at 70 days of age (postpubertal) and in group 3 sham surgery was done at same age. 20 days after first surgery, in intervention groups contralateral orchiectomy was done and in control groups random orchiectomy (left or right) was done. Blood sampling for evaluation of serum testosterone was performed just before second surgery.Result: Testis weight and the mean testicular weight per 100 g of body weight was greater in group 1 and 3. These parameters was greater in prepubertal group(group 1) than postpubertal group (3). There was no appreciable difference in serum testosterone levels in 4 groups.Conclusion: Our research demonstrated that unilateral orchidectomy resulted in compensatory hypertrophy of the remaining testis and it decreased as the animals aged. unilateral orchidectomy does not lead to reduction in serum testosterone levels and remaining testis can retrieve a normal serum testosterone level.کلیدواژه ها
Compensatory hypertrophy, Rat, Testis, Unilateral orchiectomy, Iatrogenic torsionاطلاعات بیشتر در مورد COI
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