The relationship between clinical and biochemical hyperandrogenism in women with PCOS: A systematic review

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 424

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شناسه ملی سند علمی:

ISERB03_296

تاریخ نمایه سازی: 11 خرداد 1397

چکیده مقاله:

Background: Many hirsute women with polycystic ovary syndrome (PCOS) are usually recognized with increased circulating androgen levels, whereas in some of them, the androgen levels are within the normal ranges. The aim of this review was to assess the relationship between clinical and biochemical hyperandrogenism (HA) in patients with PCOS.Methods: e searched PubMed, Scopus, Scholar Google, and Science Direct databases (2000 to 2015) to identify studies investigating clinical and biochemical parameters of HA in patients with PCOS. In all studies included, Ferriman-Gallwey (FG) score had been considered as a parameters for clinical HA and total testosterone (tT), free testosterone (fT), androstendion (A4) and dehydroepiandrosterone (DHEAS) considered as biochemical HA parameters.Result: Some studies showed correlations between FG score and tT, fT, A4, DHEAS, whereas other studies did not reported this correlations. Limited number of studies observed the associations of FG score with fT but not with tT, A4 and DHEAS. Although most studies found associations between testosterone and FG score, there is document that shows associations of DHEAS, A4 levels and FG score.Conclusion: Determination of relationship between endocrine and clinical characteristics in hirsute patients with PCOS has important implications for follow-up and management of this disorder. According to the findings, it seems that the relationship between clinical and biochemical HA is weak and it was not completely understood. However, we recommend measuring all key androgens levels including tT, fT, A4 and DHEAS to assess the HA in patients with PCOS.

نویسندگان

Mina Amiri

PhD candidate, Students Research office, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Fahimeh Ramezani Tehrani

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Fahimeh Nahidi

Department of Reproductive Health and Midwifery, Faculty of Nursing and Midwifery, Shahid beheshti University of Medical Sciences, Tehran, Iran