Nanocurcumin can hinder oxymetholone induced spematotoxicities in mice
- سال انتشار: 1396
- محل انتشار: سومین کنگره بین‌المللی تولیدمثل
- کد COI اختصاصی: ISERB03_267
- زبان مقاله: انگلیسی
- تعداد مشاهده: 443
نویسندگان
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Background: Oxymetholone (OXM), an active, edible anabolic-androgenic steroid, is widely used by athletes as performance-enhancer in high doses. Curcumin, a hydrophobic compound naturally found in the rhizome of Curcuma Longa, has confirmed antiviral, antibacterial, antifungal, anticancer, anti-inflammatory and antioxidant properties. In the present study, the effects of nanocurcumin on mouse epididymal sperm characteristics following OXM treatment were investigated.Methods: Adult male mice were randomly divided into 4 equal groups and treated orally for 35 days. Epididymal sperm parameters were analyzed following sampling.Result: Oxymetholone (5 mg/kg) administration resulted in significant epididymal sperm concentration and quality reductions. Notably, nanocurcumin (15 mg/kg) co-treatment ameliorated above-mentioned alterations.Conclusion: It seems that nanocurcumin has potential protective activities against OXM-induced spermatotoxicities in male mice.کلیدواژه ها
Curcumin, Mouse, Sperm, Oxymetholoneاطلاعات بیشتر در مورد COI
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