Association of the TNFSF13B gene rs16972194 and rs56124946 rare polymorphisms and susceptibility of preeclampsia in south Iranina women

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 403

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شناسه ملی سند علمی:

ISERB03_266

تاریخ نمایه سازی: 11 خرداد 1397

چکیده مقاله:

Background: Preeclampsia (pregnancy-related hypertension) is the most pregnancy complication, affecting 0.4% to 2.8% of all pregnancies. The etiology of preeclampsia is not completely understood, but feto-maternal immune incompatibility, oxidative stress, genetic variants and endothelial cells injuries play an important role in the pathogenesis of the disease. TNFSF13B gene is a member of tumor necrosis factor family (TNF) as a main regulator of an immune response. TNF is a pro-inflammatory cytokine inducing an endothelial cell injuries and reactive oxygen species production. This study aimed to investigate the association between the TNFSF13B gene rs16972194 and rs56124946 rare polymorphisms and preeclampsia in south Iranian women.Methods: 600 subjects including 308 women with preeclampsia and 292 healthy pregnant women were enrolled in this case-control study. Genotyping of the rs56124946 polymorphism was done using ARMS PCR and for rs16972194 using T-ARMS PCR. Statistical analyses were done by SPSS software.Result: The frequency of CC, CG, and GG genotypes in patients were 95.2, 3.1, and 1.7 percent and 97.7, 1.3 and 1 percent in controls, respectively. Significant difference was not found in the frequency of genotypes regarding the rs56124946 polymorphism. The allele related to this site did not affect the risk of disease. About 99.3% of controls and 99.7% of patients showed GG genotype for rs16972194 polymorphism. No difference in the genotype frequencies was implicated between cases and controls.Conclusion: In conclusion, the results of this study showed that the rare variants of the TNFSF13B gene not related to preeclampsia in Iran.

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