Evaluation of the risk of metabolic syndrome as a result of dietary selenium intake deficiency in PCOS patients

Background: Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in childbearing-aged women in Iran which has relatively high prevalence. The risk of metabolic syndrome (MetS) in women with PCOS compared with healthy women was found to be more than 2 times. MetS increase the complications associated with PCOS. Oxidative stress may play a role in the pathophysiology of PCOS and MetS. Selenium (Se) is a powerful antioxidant/anti-inflammatory micronutrient which decrease in PCOS patient s plasma. The aim of this study was to assess the risk of metabolic syndrome as a result of inadequate selenium intake in PCOS patients.Methods: This case-control study which was approved by the Medical Ethics Committee was conducted by convenience-sampling-method on 182 patients eligible for the study. Subjects were classified according to the Rotterdam criteria as follows: A(n=41), B(n=33), C(n=40), D(n=37) and control(without PCOS)(n=31). MetS was measured based on NCEPATPIII criteria. Assessment of dietary Selenium intake, was carried out by valid/reliable 168-items FFQ. Selenium cut-off was determined 55 μg/d according to the recommended-dietary-allowances (RDAs). Statistical analysis was performed using SPSS22 software and Fisher-exact-tests.Result: The percentage of MetS as a result of selenium deficiency in each group was as follows: A: 87.5% (n=7) (P< 0.001) B: no statistically significant differences (P> 0.05) C: 100% (n=1) (P= 0.02) D: 33.3% (n=4) P=0.03 (OR:12.4, CI:0.008-0.85)Conclusion: With regard to anti-inflammatory/antioxidant effects of selenium, dietary deficiency of this micronutrient, can be one of the modifiable factors affecting the progress of PCOS to MetS.

کلیدواژه ها:

Inflammation ، Metabolic syndrome ، Oxidative-stress ، PCOS ، Selenium