The relationship between dietary vitamin D intake and serum androgen components in polycystic ovary syndrome subgroups based on Rotterdam criteria

سال انتشار: 1396
محل انتشار: سومین کنگره بین‌المللی تولیدمثل
کد COI اختصاصی: ISERB03_201
زبان مقاله: انگلیسی
تعداد مشاهده: 430

نویسندگان

Tarbiat Modarres University, Tehran, Iran.

چکیده

Background: Polycystic ovary syndrome (PCOS) is the most common hyperandrogenic disorder in reproductive-age women in Iran which has relatively high prevalence. There is an oxidative stress and inflammatory basis in the pathogenesis of PCOS. Vitamin D (vitD) has a favorable influence in improving oxidative stress and its deficiency is also associated with obesity and insulin resistance (IR). Moreover, IR increases hyperandrogenism. At present, there is a gap about Vitamin D –androgens relationship. Thus, this study sought to assess that in PCOS subgroups.Methods: This case-control study which was approved by the Medical Ethics Committee, was conducted by convenience sampling method on 182 patients eligible for the study. Subjects were classified according to the Rotterdam criteria: A(n=41), B(n=33), C(n=40), D(n=37) and control(without any PCOS)(n=31). Androgenic components included total-testosterone(TT), free-androgen-index(FAI), sex-hormone-binding-globulin(SHBG). Assessment of dietary Vitamin D intake was carried out by valid-reliable 168-items FFQ. Statistical analysis was performed using SPSS22 software and Spearman correlation tests Result: Statistically significant correlations between vitD & androgenic components in each subgroups separately were as follows: A [TT(r:-0.5, P< 0.001), FAI (r:-0.3, P: 0.04)] B [TT(r:-0.5, P: 0.002), FAI (r:-0.6, P< 0.001)] C [TT(r:-0.31, P: 0.04), FAI (r:-0.5, P:0.001), SHBG (r: 0.3, P: 0.01)] D [TT(r:-0.5, P< 0.001), FAI (r:-0.7, P< 0.001)]. No statistically significant correlations was found in control group (P> 0.05).Conclusion: Regarding beneficial effects of vitD on androgenic components, it can be one of the modifiable factors affecting the hyperandrogenic complications of PCOS.

کلیدواژه ها

Hyperandrogenism, PCOS, Vitamin D

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.