The effect of alpha-lipoic acid supplementation on semen quality in rats with experimental varicocele induction

  • سال انتشار: 1396
  • محل انتشار: سومین کنگره بین‌المللی تولیدمثل
  • کد COI اختصاصی: ISERB03_184
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 432
دانلود فایل این مقاله

نویسندگان

Erfaneh Shaygannia

Raha pharmaceutical Company, Isfahan, Iran.

Marzeyeh Tavalaee

Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

چکیده

Background: Varicocele is the main cause of male infertility worldwide. There is a close linkage between varicocele pathogenesis and oxidative stress. It is indicated that male infertility is associated with a lower intake of some antioxidant nutrients. One of the antioxidants which recently noticed is alpha-lipoic acid (ALA) that highly used in different diseases. Recently, it is used to treat infertility. Therefore, in the present study we tried to investigate effects of ALA on semen parameters (concentration, motility and abnormal morphology) in rats with experimentally induced varicocele.Methods: Adult male Wistar rats (n=40) were divided into 4 groups of 10 animals each. Group I and II were considered as control and varicocele-induced groups, respectively. Rats received and did not receive alpha-lipoic acid for 2 months after inductions of varicocele were considered as group III and IV. Then, sperm concentration, motility and morphology were assessed in semen samples of each group.Result: sperm normal morphology, motility and concentration were significantly low in varicocele induced group compared with control group , hence, we observed significant recovery in all the semen parameters in ALA-treated group compared with un treated group.Conclusion: The present study is the first study which evaluates ALA antioxidant effect on the varicocele-induced rats. We concluded that ALA has a strong potential in neutralizing oxidant effect of ROS-induced by varicocele in morphology, motility and concentration of male rats. We suggest that further studies should be conduct on the effect of ALA in infertilities caused by varicocele in human.

کلیدواژه ها

ALA, Antioxidant, Semen parameters, Varicocele

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.