Serum magnesium levels in polycystic ovary syndrome (PCOS) patients with insulin resistance

  • سال انتشار: 1396
  • محل انتشار: سومین کنگره بین‌المللی تولیدمثل
  • کد COI اختصاصی: ISERB03_152
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 508
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نویسندگان

Maryam Kanafchian

Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran

Soleiman Mahjoub

Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran. Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Torkmahale, Babol, Iran

Sedigheh Esmaeilzadeh

Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Torkmahale, Babol, Iran

Maryam Rahsepar

School of Medicine, Babol University of Medical Sciences, Ganjafrooz Avenue, Babol, Iran

چکیده

Background: PCOS is an endocrine-metabolic disorder affecting about 7-10% women of reproductive age worldwide. Insulin resistance (IR) has been found in up to 70% of PCOS women. Magnesium deficiency is associated with the presence of diabetes mellitus type 2 and other components of the metabolic syndrome. This study primarily focused on the investigation of serum magnesium levels as well as its relation with insulin resistance in PCOS patients.Methods: In this case control study -approved by the Ethical Committee of Babol University of Medical Science- 60 cases with PCOS attending the Fatemeh Zahra Infertility and Reproductive Center, Babol, Iran along with 90 healthy age- and body mass index (BMI)- matched controls were included. PCOS group were further divided into two subgroups (IR: n=36; NIR: n=24). Serum Magnesium levels, FBS and fasting insulin were measured in both groups. Insulin resistance was assessed using Quantitative Insulin Sensitivity Check Index (QUICKI) and Homeostasis Model Assessment (HOMA-IR) indexes. Statistical analyses were done using SPSS version 16.Result: There was not statistically significant differences between magnesium levels in two groups. In PCOS-IR, Magnesium levels were inverselycorrelated with HOMA-IR (r=-0.449, p=0.006) and FBS (r=-0.509, p=0.002) and directly correlated with QUICKI (r=0.480, p=0.003).Conclusion: The findings confirm the association between serum magnesium levels and insulin resistance.

کلیدواژه ها

HOMA-IR, Insulin resistance, Magnesium, QUICKI, PCOS

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