Ovary tissue engineering: state of the art

In recent years, tissue engineering approaches have demonstrated enormous potential to restore fertility in patients who became infertile as a result of chemotherapy, uterine injuries, etc. Although transplantation of fresh or cryopreserved ovary has demonstrated success, for cancer patients who cannot undergo ovary transplantation due to the possible presence of malignant cells in their ovaries, the challenge is creating an in vitro or in vivo artificial ovary. To this aim, bioengineering of a three-dimensional system that encapsulates and protects follicles and ovarian cells is required for survival and development of artificial ovary.Despite investigations on tissue engineered strategies, the feasibility of creating whole organ constructs through these approaches is yet to be established. It proposed that with prosperous clinical translation of bioengineering technologies, these strategies hold promise as potential treatments and cures for female infertility.

کلیدواژه ها:

Female ، Infertile ، Ovary ، Tissue engineering