Comparison of The Anti-inflammatory Effect of Aqueous Extract of Melia azedirach. L Leaves with it’s the Hydro-alcoholic Extract of Plant on Male Rats

سال انتشار: 1395
محل انتشار: اولین کنفرانس ملی یافته های نوین زیست شناسی
کد COI اختصاصی: BIOC01_252
زبان مقاله: انگلیسی
تعداد مشاهده: 349

نویسندگان

M.sc Student in Biology (Animal Physiology), Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Masoud Fereidoni

Professor, Rayan Center for Neuroscience and Behavior, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Ali Asadollahi

Assistant Professor, Rayan Center for Neuroscience and Behavior, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

چکیده

Due to the presence of compounds with anti-inflammatory effects, such as flavonoids, tannins, phenolic and steroid compounds in Melia azedirach, our previous study showed that aqueous extract of the plant at dose of 200 mg/kg has Anti-inflammatory effects. According to reports on Anti-inflammatory effects of ethanol extract of similar species (Azadirach indica), the possible anti-inflammatory effect of hydro-alcoholic extract of Melia azedirach wouldn’t be unexpected. So in this study anti-inflammatory effect of Melia azedirach leaves hydro-alcoholic extract at the dose of 200 mg/kg was compared to that of the same dose on aqueous extract. Male rats (200-250gr) were divided into 5 groups: control, sham1 (i.p. aqueous extract solvent), sham2 (i.p. hydro-alcoholic extract solvent), i.p., 200 mg/kg aqueous extract and i.p., 200 mg/kg hydro-alcoholic extract. Edema was induced in the rat’s hind paw by subcutaneous injection of 0.05 ml of 2.5% formalin and paw volume was measured using plethysmometeriy before and one hour after the injection.Comparison of aqueous and hydro-alcoholic extracts of Melia azedirach showed that the aqueous extract of the plant leaves is more effective than hydro-alcoholic extract in reducing the paw edema (p< 0.05).The results indicate that aqueous extract act better than the plant hydro-alcoholic extract regard to paw edema. Maybe, water is more effective to extract the substances with anti-inflammatory effects, from the plant

کلیدواژه ها

Melia azedirach, Inflammation, plethysmometery, Rats, hydro-alcoholic extract

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