Monire Zarei - Undergraduate student of Midwifery, Islamic Azad University of Isfahan (Khorasgan), Isfahan, Iran
Arezoo Rezaei - MSc graduate of Consultation in Midwifery, Instructor of Nursing and midwifery faculty of Islamic Azad University of Isfahan (khorasgan) , Isfahan, Iran

Introduction: G6PD deficiency is one of the most common defective enzymes in red blood cells. This enzyme deficiency is one of the causes of acute hemolysis in infancy and childhood. Neonatal hemolysis may lead to dangerous complications such as anemia, hyperbilirubinemia and kern icterus. Therefore, this study aims to review the relation between G6PD deficiency and neonatal hyperbilirubinemia. Materials and Methods: In this overview, 50 papers were extracted using keywords such as infancy or newborn, Jaundice, G6PD and Bilirubin in international databases including PubMed, Science Direct, SID and Google Scholar. After the evaluation of entry and exit criteria, 20 papers were excluded based on the Prisma checklist, 30 papers were listed from 2004 to 2016 and data were extracted. Findings: Jaundice is one of the most common neonatal outcomes that occurs in 60% of infants and 80% of premature infants in the first week of life. One of the recognizable causes of neonatal jaundice is the deficiency of the G6PD enzyme. Lack of G6PD activity is an inherited disorder associated with X-linked recessive disorders and leads to red blood cell susceptibility to oxidative substances (medications, chemical agents, resulting in hemolysis, with various clinical manifestations, including neonatal jaundice, acute hemolysis and icterus, in contact with bean (favism) and also spherocytosis hemolytic anemia.Conclusion: The deficiency of G6PD enzyme is relatively common in the infected patients with icterus (3.2%) and may lead to malignant hyperbilirubinemia, which, if not detected and timely treated, leads to complications such as coronary anthrax, so Early screening of infants is recommended for G6PD, especially in our country and in countries with a high prevalence of G6PD deficiency, and with the timely diagnosis and taking of necessary measures, the following side effects can be prevented.

Neonatal, Jaundice, G6PD and Bilirubin