Classifying the Evolutionary and Ecological features of Neoplasms

Neoplasms undergo a process of cell-level evolution driven by genetic and epigenetic changes over time. The microenvironement s alterations of neoplastic cells and it s positive or negative effects are very significant for patient s survival or failure of treatment.Unfortunately, there is not any proposed system for making a clinical distinction between different evolving tumors regarding their alterations and whether theses alterations benefited the patients or not. In this article, by reviewing the four relevant components, we propose a frame work for classifying tumors. By considering indices such as evolutionary index which evaluate the changes of diversity of neoplastic cells over time; and ecologic index which is concentrated on effects of these changes neoplastic cell survival, we represent comprehensive classification of tumor heterogeneity. This classification is mentioned in some reach resources. Using this measurement for predicting the effect of alteration are very important study tools.Finally, development of this classification system enables clinicians to do a personalized optional intervention according to the evolvability of the patient s tumor. These indices provide a common lexicon for communicating about how neoplasms change in response to interventions, with potential implications for clinical trials, personalized medicine and basic cancer research.

کلیدواژه ها:

neoplasm ، Eco-index ، Evo-index ، cancer heterogeneity ، measurement model