Can seasonal Variations affect breast cancer (Review)

Introduction: Breast cancer is the most common female cancer. A seasonal variation in the initial detection of breast cancer has been previously observed in pre-menopausal women. The aim of this review was to investigate the Seasonal effects on Mechanisms associated with cancer .Methods: A search was conducted in the google scholar, Pubmed, Science Direct electronic databases. Articles were relevant for seasonal variations in cancer mechanisms specialized breast cancer rates and detection of breast. Variables were compared using one-way parametric analysis, SPSS (version18) and SAS version 9.3. Result: Female breast cancer patients exhibited an improved survival in the summer as compared to the winter at all latitudes. There was no significant association between later stage of breast cancer and travel. Seasonal changes in detection of breast cancer may in part relate to seasonal changes in hormone responsiveness within tumor tissue. The abnormal reduction of serum melatonin and promote tumor growth and contribute to the decreased survival seen in wintertime in winter detectors of breast cancer observed compared with summer detectors.Conclusions: The relatively normal seasonal profile of melatonin observed in summer detectors could allow increased ovarian steroidogenesis in spring/summer with a resulting increase in tumor growth and consequent rise in tumor detection rate at this time. Cyclic changes in tumor growth mediated by the effects of melatonin on ovarian function and vitamin D have a protective role in cancer survival. As a result, seasonal Variations can be effective in breast cancer.

کلیدواژه ها:

Seasonal Variation ، vitamin D ، Hormone ، breast cancer